Newcastle University
MoveLab

Centre for Life

Newcastle upon Tyne
United Kingdom

 

ncl.ac.uk

movelab.org

 

Project leader

 
Dr. Grainne Gorman
 
Phone +44 191 222 6365
E-Mail  

Project staff

 
Prof. Michael Trenell
 
Phone +44 191 222 6935
E-Mail  

Institute presentation

Newcastle University has an excellent pedigree in research and teaching with a strong interdisciplinary research base. In the UK it ranks in the top 5 for both hospital- and laboratory-based clinical subjects, with two-thirds of the outputs classified as world leading or internationally excellent in the areas of ageing, chronic disease, genetics and stem cells.

 

Professor Mike Trenell is an NIHR Research Fellow, a significant focus of his research has been on how increased physical activity and exercise can be used as a clinical therapy in metabolic disorders (Type 2 diabetes and non-alcoholic fatty liver disease), neuromuscular disease, ageing and in promoting lifelong health and wellbeing. He established Move Lab in 2009. The objective of Move Lab is to provide a complete translational research platform; building both the evidence base of movement as a clinical therapy and a pathway for delivery into care. The Move Lab is an innovative team within the university bringing together staff and expertise from the Institute of cellular medicine, Institute of Genetic Medicine and the Institute of Health and Ageing assisted through funding from the Medical Research Council.

 

The Lab has a program of studies investigating the interaction of physical inactivity, physical activity, and exercise upon molecular, genetic and metabolic function with collaborators in the UK and overseas. Addressing two key questions: what type of activity is best and how much is needed to use physical activity and exercise as a therapy? These studies are identifying the dose response of both resistance and aerobic exercise upon clinical outcomes. The team are working with clinical care and patient groups to move these findings into clinical practice. We are developing the UK’s first accredited professional and patient development pathways for physical activity and exercise for use as a clinical therapy in primary care. This is an exciting area which is expanding rapidly.

 


 

 

MRC Centre for Neuromuscular Disease

International Centre for Life

Central Parkway

Newcastle upon Tyne

NE1 3BZ

United Kingdom.

 

treat-nmd.eu

ncl.ac.uk/igm/

cnmd.ac.uk

 

 

Project leader

 
Prof. Hanns Lochmüller
 
Phone +44 (0) 1912418602
E-Mail  

Project staff

 
Libby Wood
 
Phone +44 (0) 1912418640
E-Mail  

Institute presentation

The MRC Centre for Neuromuscular Diseases at Newcastle is a clinical and research reference centre that forms part of the Institute of Genetic Medicine, a leading research institute within the university that works together with the Newcastle hospitals. It is an internationally recognised centre of excellence for diagnosis, management and research into inherited neuromuscular diseases. In partnership with the Institutes of Neurology and Child Health at University College London, the Newcastle centre was selected to be part of the UK Medical Research Council’s first translational research centre for neuromuscular diseases, an initiative which aims to promote multidisciplinary translational research activity in these diseases.

 

Newcastle houses the regional diagnostic service for neuromuscular diseases for the northern region in the United Kingdom. The clinical team based at the centre runs paediatric and adult clinics throughout the North of England seeing around 300 myotonic dystrophy patients annually. Clinics are held both in Newcastle and at a range of other locations throughout the region, in conjunction with local physiotherapists and other local staff. The centre has collaborative links with colleagues in cardiology, respiratory support, orthopaedics, neuropathology and other specialities. It welcomes visiting doctors and other staff for specialised training in neuromuscular disease diagnosis and management.

Professors Kate Bushby, Volker Straub and Hanns Lochmüller head the Centre and hold joint appointments between Newcastle University and the National Health Service (NHS). Their time is split between research and clinical commitments, both of which primarily focus on muscle disease. Research in the centre is supported by grants from numerous national and international awarding bodies. The centre is a globally leading neuromuscular clinical trial site involved in multiple industry-sponsored trials and is at the forefront of research and care for neuromuscular disorders.

 

The centre is highly active internationally in rare disease and neuromuscular networking and healthcare policy initiatives. Newcastle is host to the coordination team for RD-Connect; creating a global platform to bring together information from multiple sources that can facilitate research into rare disease. Since 2012 it has coordinated the EUCERD Joint Action on Rare Diseases, responsible for aiding the European Commission with the preparation and implementation of community activities in the field of rare diseases. Staff have also been in key roles in other European projects, including BIO-NMD, CARE-NMD, NMD-Chip and EuroBioBank, and Neuromics.

The Institute of Genetic Medicine is also home to the TREAT-NMD Alliance. TREAT-NMD has been influential in the creation of patient registries for neuromuscular disorders and Newcastle coordinates the UK Myotonic Dystrophy Patient Registry.

 

Myotonic Dystrophy Support Group

Website: www.myotonicdystrophysupportgroup.org

Email: This email address is being protected from spambots. You need JavaScript enabled to view it.

 

Muscular Dystrophy Campaign

Website: www.muscular-dystrophy.org

Email: This email address is being protected from spambots. You need JavaScript enabled to view it.

 

UK Myotonic Dystrophy Patient Registry

Website: www.dm-registry.org/uk

Email: This email address is being protected from spambots. You need JavaScript enabled to view it.

 

Patient Registries and Trial Readiness in Myotonic Dystrophy- TREAT-NMD/Marigold International Workshop Report:

http://www.sciencedirect.com/science/article/pii/S0960896609005902

 

UK Myotonic Dystrophy Patient Registry leaflet:

http://www.treat-nmd.eu/downloads/file/DMLeaflet_April2012_Version1.0.pdf