The aim of OPTIMISTIC:
Improve clinical practice for patients suffering from myotonic dystrophy type 1 (DM1) 

We hypothesize that a comparable but DM1-specific CBT intervention, aimed at the fatigue maintaining beliefs and behaviours, tailored to the individual DM1 patient, will lead to a significant reduction of fatigue and improved quality of life.


Here you will find local organisations that provide assistance and information to people affected by DM1 and their families



Here you will find your national patient registry, being part of a registry may give you the opportunity to take part in clinical research like OPTIMISTIC.


NEW: Newsletter 4 click here

This newsletter will answer some frequently asked questions and provide more information on fatigue and how it affects people with DM1.

Here you will find the first, second and third OPTIMISTIC newsletter (English, German, French and Dutch version).


Information for patients

Read more

 GENEActiv, raw data accelerometer for objective behavioural measurement



 Openclinica, test and training



Test randomisation system

l’Assistance Publique – Hôpitaux de Paris
Hôpital Henri Mondor Créteil
51 avenue du Maréchal de Lattre de Tassigny
4000 Créteil, France

Project leader

Guillaume Bassez
Phone +33 1 49 81 2111


Institute presentation

Assistance Publique-Hôpitaux de Paris (APHP) is the biggest teaching hospital in Europe, federating 39 different hospitals and groups of hospitals mainly located in Paris and its suburban area. This is also the largest employer in the Paris region with 90 000 people working for this public institution representing more than 150 different jobs. With more than 3 000 hospital physicians, including 1 000 professors and more than 6 000 residents and medical students, APHP’s staff covers all the major medical specialities. As public health institution, APHP pursues 3 main missions: healthcare delivery, medical and paramedical teaching, and biomedical and clinical research. APHP teams develop high quality research activities, including European and international research projects.

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