Radboud University Nijmegen Medical Centre


Radboud University Nijmegen Medical Centre
Expert Centre for Chronic Fatigue

Internal mail 916, Postbox 9101

6500 HB Nijmegen
The Netherlands



Project leader

Hans Knoop, Phd
Clinical psychologist
Phone +31 24 3610042
Fax +31 24 3610040

Project staff

Sacha Bouman
Clinical psychologist
Phone +24 3610042
Fax +24 3610040

Institute presentation

The Expert Centre for Chronic fatigue (ECCF) of the Radboud University Nijmegen Medical Centre  is a centre of excellence with respect to the study of chronic fatigue. The ECCF has developed cognitive behavioural interventions for chronic fatigue in  different disorders and medical conditions. These interventions are aimed at the reduction of fatigue and fatigue related disabilities. Several randomised controlled trials were conducted by the ECCF which showed that these interventions were effective. The ECCF is also actively involved in the implementation of evidence based cognitive-behavioural interventions for chronic fatigue in clinical practice. In recent years the ECCF participated in research into chronic fatigue in neuromuscular disorders. Perpetuating cognitive behavioural factors were identified and interventions were developed.


In OPTIMISTIC the ECCF will develop a cognitive behavioural intervention (CBT) aimed at improving the  quality of life of patients with DM1.  During CBT patients and their significant others will learn how to change the way they cope with fatigue and a reduced initiative. Both are highly prevalent in DM1 and lead to impairments in daily life. CBT  should help patients to reduce the impact of these symptoms on daily life.

This website uses cookies to improve your experience. We'll assume you're ok with this, but you can opt-out if you wish. Until you give your consent, only those cookies necessary to maintain the website's functionality are active. When you choose "OK", so called third-party non-functional cookies (e.g. GDPR-conform Google Analytics) may also become active. Please be aware that the website's functionality may be restricted if you choose "DECLINE". You can revoke your choice at any time by clearing your browser cache/history and updating your selection. Please also view our privacy policy.
Ok Decline